| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIN |
| Gene ID: |
22944 |
| Uniprot ID: |
KIN17_HUMAN |
| Immunogen Region: |
180-270 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-270 of human KIN (NP_036443.1). |
| Immunogen Sequence: |
GLEGKEQEVPTFTELSREND EEKVTFNLSKGACSSSGATS SKSSTLGPSALKTIGSSASV KRKESSQSSTQSKEKKKKKS ALDEIMEIEEE |
| Tissue Specificity | Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). |
| Function | Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro. |
| Protein Name | Dna/Rna-Binding Protein Kin17Binding To Curved DnaKin - Antigenic Determinant Of Reca Protein Homolog |
| Database Links | Reactome: R-HSA-8876725 |
| Cellular Localisation | NucleusCytoplasmDuring S PhaseStrongly Associated With The Nuclear MatrixAnd To Chromosomal Dna In The Presence Of Dna DamageAlso Shows Cytoplasmic Localization In Elongated Spermatids |
| Alternative Antibody Names | Anti-Dna/Rna-Binding Protein Kin17 antibodyAnti-Binding To Curved Dna antibodyAnti-Kin - Antigenic Determinant Of Reca Protein Homolog antibodyAnti-KIN antibodyAnti-BTCD antibodyAnti-KIN17 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
