| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF16B |
| Gene ID: | 55614 |
| Uniprot ID: | KI16B_HUMAN |
| Immunogen Region: | 1-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human KIF16B (NP_078980.3). |
| Immunogen Sequence: | MASVKVAVRVRPMNRREKDL EAKFIIQMEKSKTTITNLKI PEGGTGDSGRERTKTFTYDF SFYSADTKSPDYVSQEMVFK TLGTDVVKSAFEGYNACVFA YGQTGSGKSYTMMGNSGDSG LIPRICEGLFSRINETTRWD EASFRTEVSYLEIYNERVRD LLRRKSSKTFNLRVREHPKE GPYVEDLSKHLVQNYGDVEE LMDAGNINRT |
| Tissue Specificity | Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). |
| Function | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. |
| Protein Name | Kinesin-Like Protein Kif16b Sorting Nexin-23 |
| Database Links | Reactome: R-HSA-6811434 Reactome: R-HSA-983189 |
| Cellular Localisation | Cytoplasm Cytoskeleton Early Endosome Membrane Spindle It Is Unclear Whether Association With Endosomes Is Mediated Via Phosphatidylinositol 3-Phosphate (Ptdins(3)P)-Binding Or Via Its Interaction With Rab14 |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif16b antibody Anti-Sorting Nexin-23 antibody Anti-KIF16B antibody Anti-C20orf23 antibody Anti-KIAA1590 antibody Anti-SNX23 antibody |
Information sourced from Uniprot.org