Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes.in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. |
Protein Name | Lysine-Specific Demethylase 5dHistocompatibility Y AntigenH-YHistone Demethylase Jarid1dJumonji/Arid Domain-Containing Protein 1dProtein SmcyHistone H3-Trimethyl-L-Lysine(4 Demethylase 5d |
Database Links | Reactome: R-HSA-3214842 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5d antibodyAnti-Histocompatibility Y Antigen antibodyAnti-H-Y antibodyAnti-Histone Demethylase Jarid1d antibodyAnti-Jumonji/Arid Domain-Containing Protein 1d antibodyAnti-Protein Smcy antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5d antibodyAnti-KDM5D antibodyAnti-HY antibodyAnti-HYA antibodyAnti-JARID1D antibodyAnti-KIAA0234 antibodyAnti-SMCY antibody |
Information sourced from Uniprot.org