| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNU1 (920-1149) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNU1 |
| Gene ID: |
157855 |
| Uniprot ID: |
KCNU1_HUMAN |
| Immunogen Region: |
920-1149 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2). |
| Immunogen Sequence: |
LELLQMLVTGGVSSQLEQHL DKDKVYGVADSCTSLLSGRN RCKLGLLSLHETILSDVNPR NTFGQLFCGSLDLFGILCVG LYRIIDEEELNPENKRFVIT RPANEFKLLPSDLVFCAIPF STACYKRNEEFSLQKSYEIV NKASQTTETHSDTNCPPTID SVTETLYSPVYSYQPRTNSL SFPKQIAWNQSRTNSIISSQ IPLGDNAKENERKTSDEVYD EDPFAYSEPL |
| Tissue Specificity | Testis-specific. |
| Function | Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. |
| Protein Name | Potassium Channel Subfamily U Member 1Calcium-Activated Potassium Channel Subunit Alpha-3Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3Kca5Slowpoke Homolog 3 |
| Database Links | Reactome: R-HSA-1300642 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily U Member 1 antibodyAnti-Calcium-Activated Potassium Channel Subunit Alpha-3 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3 antibodyAnti-Kca5 antibodyAnti-Slowpoke Homolog 3 antibodyAnti-KCNU1 antibodyAnti-KCNMA3 antibodyAnti-KCNMC1 antibodyAnti-SLO3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
