| Tissue Specificity | Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain. |
| Post Translational Modifications | N-glycosylation is necessary for targeting to lysosomes. |
| Function | K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux. Isoform 2: Does not display channel activity. |
| Protein Name | Potassium Channel Subfamily K Member 6Inward Rectifying Potassium Channel Protein Twik-2Twik-Originated Similarity Sequence |
| Database Links | Reactome: R-HSA-1299308Reactome: R-HSA-5576886 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 6 antibodyAnti-Inward Rectifying Potassium Channel Protein Twik-2 antibodyAnti-Twik-Originated Similarity Sequence antibodyAnti-KCNK6 antibodyAnti-TOSS antibodyAnti-TWIK2 antibody |
Information sourced from Uniprot.org
