| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNJ13 (160-360) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNJ13 |
| Gene ID: |
3769 |
| Uniprot ID: |
KCJ13_HUMAN |
| Immunogen Region: |
160-360 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-360 of human KCNJ13 (NP_002233.2). |
| Immunogen Sequence: |
IARPKNRAFSIRFTDTAVVA HMDGKPNLIFQVANTRPSPL TSVRVSAVLYQERENGKLYQ TSVDFHLDGISSDECPFFIF PLTYYHSITPSSPLATLLQH ENPSHFELVVFLSAMQEGTG EICQRRTSYLPSEIMLHHCF ASLLTRGSKGEYQIKMENFD KTVPEFPTPLVSKSPNRTDL DIHINGQSIDNFQISETGLT E |
| Tissue Specificity | Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord. |
| Post Translational Modifications | Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. |
| Protein Name | Inward Rectifier Potassium Channel 13Inward Rectifier K(+ Channel Kir7.1Potassium Channel - Inwardly Rectifying Subfamily J Member 13 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Inward Rectifier Potassium Channel 13 antibodyAnti-Inward Rectifier K(+ Channel Kir7.1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 13 antibodyAnti-KCNJ13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
