| Host: |
NZ White Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Nz White Rabbit polyclonal antibody anti-KCNJ12 (Cytoplasmic) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Shipped as lyophilised. Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material. |
| Purification: |
Ammonium sulphate precipitation |
| Dilution Range: |
A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Kcnj12 |
| Gene ID: |
16515 |
| Uniprot ID: |
KCJ12_MOUSE |
| Immunogen Region: |
Cytoplasmic |
| Specificity: |
Specific for KCNJ12. |
| Immunogen: |
A synthetic peptide from the cytoplasmic domain of rat KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse. |
| Function | Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 12Inward Rectifier K(+ Channel Kir2.2Irk-2Potassium Channel - Inwardly Rectifying Subfamily J Member 12 |
| Database Links | Reactome: R-MMU-1296041Reactome: -MMU-1296053Reactome: -MMU-5576886Reactome: -MMU-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 12 antibodyAnti-Inward Rectifier K(+ Channel Kir2.2 antibodyAnti-Irk-2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 12 antibodyAnti-Kcnj12 antibodyAnti-Irk2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
