| Host: |
NZ White Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Rat/Mouse/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Nz White Rabbit polyclonal antibody anti-KCNJ10 (330-379) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Shipped as lyophilised. Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material. |
| Purification: |
Ammonium sulphate precipitation |
| Dilution Range: |
A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNJ10 |
| Gene ID: |
3766 |
| Uniprot ID: |
KCJ10_HUMAN |
| Immunogen Region: |
330-379 |
| Specificity: |
Specific for KCNJ10. |
| Immunogen: |
A synthetic peptide from aa region 330-379 of human KCNJ10 conjugated to blue carrier protein was used as the antigen. |
| Function | May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules.this process is critical for Na(+) reabsorption at the tubules. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 10Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1Inward Rectifier K(+ Channel Kir1.2Potassium Channel - Inwardly Rectifying Subfamily J Member 10 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296067Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneIn Kidney Distal Convoluted TubulesLocated In The Basolateral Membrane Where It Colocalizes With Kcnj16 |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 10 antibodyAnti-Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1 antibodyAnti-Inward Rectifier K(+ Channel Kir1.2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 10 antibodyAnti-KCNJ10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
