| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IWS1 (570-819) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IWS1 |
| Gene ID: |
55677 |
| Uniprot ID: |
IWS1_HUMAN |
| Immunogen Region: |
570-819 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 570-819 of human IWS1 (NP_060439.2). |
| Immunogen Sequence: |
AAEEDRQLNNQKKPALKKLT LLPAVVMHLKKQDLKETFID SGVMSAIKEWLSPLPDRSLP ALKIREELLKILQELPSVSQ ETLKHSGIGRAVMYLYKHPK ESRSNKDMAGKLINEWSRPI FGLTSNYKGMTREEREQRDL EQMPQRRRMNSTGGQTPRRD LEKVLTGEEKALRPGDPGFC ARARVPMPSNKDYVVRPKWN VEMESSRFQATSKKGISRLD KQMRKFTDIRKKSRSAHAV |
| Post Translational Modifications | Phosphorylation increases its interaction with PSIP1. |
| Function | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. |
| Protein Name | Protein Iws1 HomologIws1-Like Protein |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-674695Reactome: R-HSA-75955 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Iws1 Homolog antibodyAnti-Iws1-Like Protein antibodyAnti-IWS1 antibodyAnti-IWS1L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
