| Function | Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro). May play a role in mRNA nuclear export. (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. The BTB and Kelch domains are required for splicing activity. Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF. |
| Protein Name | Influenza Virus Ns1a-Binding ProteinNs1-BpNs1-Binding ProteinAryl Hydrocarbon Receptor-Associated Protein 3Kelch-Like Protein 39 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusNucleoplasmAssociated With Actin FilamentsLocalization Related To Speckle Domains Which Correspond To Interchromatin Granules And Are Enriched In Factors Involved In Pre-Mrna SplicingFollowing Influenza A Virus InfectionRedistribution From Speckles To A More Diffuse Distribution In The Nucleoplasm |
| Alternative Antibody Names | Anti-Influenza Virus Ns1a-Binding Protein antibodyAnti-Ns1-Bp antibodyAnti-Ns1-Binding Protein antibodyAnti-Aryl Hydrocarbon Receptor-Associated Protein 3 antibodyAnti-Kelch-Like Protein 39 antibodyAnti-IVNS1ABP antibodyAnti-ARA3 antibodyAnti-FLARA3 antibodyAnti-KIAA0850 antibodyAnti-KLHL39 antibodyAnti-NS1 antibodyAnti-NS1BP antibodyAnti-HSPC068 antibody |
Information sourced from Uniprot.org
