| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IVL |
| Gene ID: | 3713 |
| Uniprot ID: | INVO_HUMAN |
| Immunogen Region: | 416-585 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 416-585 of human IVL (NP_005538.2). |
| Immunogen Sequence: | QERQVEHLEQQVGQLKHLEE QEGQLKHLEQQQGQLEVPEQ QVGQPKNLEQEEKQLELPEQ QEGQVKHLEKQEAQLELPEQ QVGQPKHLEQQEKHLEHPEQ QDGQLKHLEQQEGQLKDLEQ QKGQLEQPVFAPAPGQVQDI QPALPTKGEVLLPVEHQQQK QEVQWPPKHK |
| Tissue Specificity | Keratinocytes of epidermis and other stratified squamous epithelia. |
| Post Translational Modifications | Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide. |
| Function | Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. |
| Protein Name | Involucrin |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | CytoplasmConstituent Of The Scaffolding Of The Cornified Envelope |
| Alternative Antibody Names | Anti-Involucrin antibodyAnti-IVL antibody |
Information sourced from Uniprot.org