Anti-IL3 antibody [SAA1520] (STJA0019948)

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STJA0019948
£341.50 - £1,447.50
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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Interleukin-3 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1520
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: IL3
Gene ID: 3562
Uniprot ID: IL3_HUMAN
Function Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
Protein Name Interleukin-3
Il-3
Hematopoietic Growth Factor
Mast Cell Growth Factor
Mcgf
Multipotential Colony-Stimulating Factor
P-Cell-Stimulating Factor
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-8939247
Reactome: R-HSA-912526
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-3 antibody
Anti-Il-3 antibody
Anti-Hematopoietic Growth Factor antibody
Anti-Mast Cell Growth Factor antibody
Anti-Mcgf antibody
Anti-Multipotential Colony-Stimulating Factor antibody
Anti-P-Cell-Stimulating Factor antibody
Anti-IL3 antibody

Information sourced from Uniprot.org