| Tissue Specificity | Expressed in neutrophils (at protein level). Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. Isoforms 1, 3, 4, 5, 6, 7, 8 and 9: Widely expressed. |
| Post Translational Modifications | N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor. |
| Function | High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5: Does not bind IL15. Isoform 6: Does not bind IL15. Isoform 7: Does not bind IL15. Isoform 8: Does not bind IL15. |
| Protein Name | Interleukin-15 Receptor Subunit AlphaIl-15 Receptor Subunit AlphaIl-15r-AlphaIl-15raCd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit AlphaSil-15 Receptor Subunit AlphaSil-15r-AlphaSil-15ra |
| Database Links | Reactome: R-HSA-8983432 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinNucleus MembraneCell SurfaceMainly Found Associated With The Nuclear MembraneIsoform 5: Endoplasmic Reticulum MembraneGolgi Apparatus MembraneCytoplasmic Vesicle MembraneIsoform 5Isoform 6Isoform 7 And Isoform 8 Are Associated With Endoplasmic ReticulumGolgi And Cytoplasmic VesiclesBut Not With The Nuclear MembraneIsoform 6: Endoplasmic Reticulum MembraneIsoform 7: Endoplasmic Reticulum MembraneIsoform 8: Endoplasmic Reticulum MembraneSoluble Interleukin-15 Receptor Subunit Alpha: SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Interleukin-15 Receptor Subunit Alpha antibodyAnti-Il-15 Receptor Subunit Alpha antibodyAnti-Il-15r-Alpha antibodyAnti-Il-15ra antibodyAnti-Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha antibodyAnti-Sil-15 Receptor Subunit Alpha antibodyAnti-Sil-15r-Alpha antibodyAnti-Sil-15ra antibodyAnti-IL15RA antibody |
Information sourced from Uniprot.org
