• Human peripheral blood lymphocytes were stained with Anti-IgD antibody (STJA0000972) (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.

Anti-IGHD antibody [IA6-2] {APC} (STJA0000972)

SKU:
STJA0000972

£152.50 - £368.50
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Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Immunoglobulin heavy constant delta is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: IA6-2
Conjugation: APC
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: IGHDUniprot ID=IGHD_HUMAN"
Function Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Protein Name Immunoglobulin Heavy Constant Delta
Ig Delta Chain C Region
Ig Delta Chain C Region Nig-65
Ig Delta Chain C Region Wah
Cellular Localisation Isoform 1: Secreted
Isoform 2: Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Immunoglobulin Heavy Constant Delta antibody
Anti-Ig Delta Chain C Region antibody
Anti-Ig Delta Chain C Region Nig-65 antibody
Anti-Ig Delta Chain C Region Wah antibody
Anti-IGHD antibody

Information sourced from Uniprot.org

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