• Immunofluorescence analysis of HeLa cells using IGF2 Polyclonal Antibody (STJ115940) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Anti-IGF2 antibody (26-156) (STJ115940)

SKU:
STJ115940

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Host: Rabbit
Applications: IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IGF2 (26-156) is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IGF2
Gene ID: 3481
Uniprot ID: IGF2_HUMAN
Immunogen Region: 26-156
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-156 of human IGF2 (NP_000603.1).
Immunogen Sequence: FYFSRPASRVSRRSRGIVEE CCFRSCDLALLETYCATPAK SERDVSTPPTVLPDNFPRYP VGKFFQYDTWKQSTQRLRRG LPALLRARRGHVLAKELEAF RE
Tissue Specificity Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.
Post Translational Modifications O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99. Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
Function The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Protein Name Insulin-Like Growth Factor Ii
Igf-Ii
Somatomedin-A
T3m-11-Derived Growth Factor Cleaved Into - Insulin-Like Growth Factor Ii - Insulin-Like Growth Factor Ii Ala-25 Del - Preptin
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-2404192
Reactome: R-HSA-2428928
Reactome: R-HSA-2428933
Reactome: R-HSA-381426
Cellular Localisation Secreted
Alternative Antibody Names Anti-Insulin-Like Growth Factor Ii antibody
Anti-Igf-Ii antibody
Anti-Somatomedin-A antibody
Anti-T3m-11-Derived Growth Factor Cleaved Into - Insulin-Like Growth Factor Ii - Insulin-Like Growth Factor Ii Ala-25 Del - Preptin antibody
Anti-IGF2 antibody
Anti-PP1446 antibody

Information sourced from Uniprot.org

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