| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ID2 (75-134) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ID2 |
| Gene ID: |
3398 |
| Uniprot ID: |
ID2_HUMAN |
| Immunogen Region: |
75-134 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 75-134 of human ID2 (NP_002157.2). |
| Immunogen Sequence: |
LQIALDSHPTIVSLHHQRPG QNQASRTPLTTLNTDISILS LQASEFPSELMSNDSKALCG |
| Tissue Specificity | Highly expressed in early fetal tissues, including those of the central nervous system. |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. |
| Protein Name | Dna-Binding Protein Inhibitor Id-2Class B Basic Helix-Loop-Helix Protein 26Bhlhb26Inhibitor Of Dna Binding 2Inhibitor Of Differentiation 2 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Dna-Binding Protein Inhibitor Id-2 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 26 antibodyAnti-Bhlhb26 antibodyAnti-Inhibitor Of Dna Binding 2 antibodyAnti-Inhibitor Of Differentiation 2 antibodyAnti-ID2 antibodyAnti-BHLHB26 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
