| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Human IgM (1-453) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S2MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IGHMUniprot ID=IGHM_HUMAN" |
| Immunogen Region: |
1-453 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-453 of human IgM (P01871). |
| Immunogen Sequence: |
GSASAPTLFPLVSCENSPSD TSSVAVGCLAQDFLPDSITF SWKYKNNSDISSTRGFPSVL RGGKYAATSQVLLPSKDVMQ GTDEHVVCKVQHPNGNKEKN VPLPVIAELPPKVSVFVPPR DGFFGNPRKSKLICQATGFS PRQIQVSWLREGKQVGSGVT TDQVQAEAKESGPTTYKVTS TLTIKESDWLGQSMFTCRVD HRGLTFQQNASSMCVPDQDT AIRVFAIPPSFASIFLTKS |
| Function | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. |
| Protein Name | Immunoglobulin Heavy Constant MuIg Mu Chain C RegionIg Mu Chain C Region BotIg Mu Chain C Region GalIg Mu Chain C Region Ou |
| Cellular Localisation | Isoform 1: SecretedDuring DifferentiationB-Lymphocytes Switch From Expression Of Membrane-Bound Igm To Secretion Of IgmIsoform 2: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Immunoglobulin Heavy Constant Mu antibodyAnti-Ig Mu Chain C Region antibodyAnti-Ig Mu Chain C Region Bot antibodyAnti-Ig Mu Chain C Region Gal antibodyAnti-Ig Mu Chain C Region Ou antibodyAnti-IGHM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
