||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody Anti-3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (30-110aa) is suitable for use in Western Blot and ELISA.
||Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
||3BHS1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||WB 1:500-2000ELISA 1:5000-20000
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||3BHS1 polyclonal antibody detects endogenous levels of protein.
||Synthesized peptide derived from human 3BHS1 protein.
| Function || A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). |
| Protein Name || 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 13 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type I3-Beta-Hsd I3-Beta-Hydroxy-5-Ene Steroid Dehydrogenase3-Beta-Hydroxy-Delta(5-Steroid Dehydrogenase3-Beta-Hydroxysteroid 3-DehydrogenaseDelta-5-3-Ketosteroid IsomeraseDihydrotestosterone OxidoreductaseSteroid Delta-IsomeraseTrophoblast Antigen Fdo161g |
| Database Links || Reactome: R-HSA-193048Reactome: R-HSA-193993Reactome: R-HSA-194002 |
| Cellular Localisation || Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMitochondrion Membrane |
| Alternative Antibody Names || Anti-3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1 antibodyAnti-3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type I antibodyAnti-3-Beta-Hsd I antibodyAnti-3-Beta-Hydroxy-5-Ene Steroid Dehydrogenase antibodyAnti-3-Beta-Hydroxy-Delta(5-Steroid Dehydrogenase antibodyAnti-3-Beta-Hydroxysteroid 3-Dehydrogenase antibodyAnti-Delta-5-3-Ketosteroid Isomerase antibodyAnti-Dihydrotestosterone Oxidoreductase antibodyAnti-Steroid Delta-Isomerase antibodyAnti-Trophoblast Antigen Fdo161g antibodyAnti-HSD3B1 antibodyAnti-3BH antibodyAnti-HSDB3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance