| Tissue Specificity | Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets. |
| Function | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. |
| Protein Name | Very-Long-Chain 3-Oxoacyl-Coa Reductase17-Beta-Hydroxysteroid Dehydrogenase 1217-Beta-Hsd 123-Ketoacyl-Coa ReductaseKarEstradiol 17-Beta-Dehydrogenase 12Short Chain Dehydrogenase/Reductase Family 12c Member 1 |
| Database Links | Reactome: R-HSA-193048Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Very-Long-Chain 3-Oxoacyl-Coa Reductase antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase 12 antibodyAnti-17-Beta-Hsd 12 antibodyAnti-3-Ketoacyl-Coa Reductase antibodyAnti-Kar antibodyAnti-Estradiol 17-Beta-Dehydrogenase 12 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 12c Member 1 antibodyAnti-HSD17B12 antibodyAnti-SDR12C1 antibody |
Information sourced from Uniprot.org
