| Tissue Specificity | Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. |
| Protein Name | Homeodomain-Only ProteinLung Cancer-Associated Y ProteinNot Expressed In Choriocarcinoma Protein 1Odd Homeobox Protein 1 |
| Database Links | Reactome: R-HSA-9725554 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Homeodomain-Only Protein antibodyAnti-Lung Cancer-Associated Y Protein antibodyAnti-Not Expressed In Choriocarcinoma Protein 1 antibodyAnti-Odd Homeobox Protein 1 antibodyAnti-HOPX antibodyAnti-HOD antibodyAnti-HOP antibodyAnti-LAGY antibodyAnti-NECC1 antibodyAnti-OB1 antibody |
Information sourced from Uniprot.org
