| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:10000-1:40000IHC-P:1:600-1:6000IF/ICC:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
HOPX |
| Gene ID: |
84525 |
| Uniprot ID: |
HOP_HUMAN |
| Immunogen Region: |
1-73 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human HOPX (NP_631957.1). |
| Immunogen Sequence: |
MSAETASGPTEDQVEILEYN FNKVDKHPDSTTLCLIAAEA GLSEEETQKWFKQRLAKWRR SEGLPSECRSVTD |
| Tissue Specificity | Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. |
| Protein Name | Homeodomain-Only ProteinLung Cancer-Associated Y ProteinNot Expressed In Choriocarcinoma Protein 1Odd Homeobox Protein 1 |
| Database Links | Reactome: R-HSA-9725554 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Homeodomain-Only Protein antibodyAnti-Lung Cancer-Associated Y Protein antibodyAnti-Not Expressed In Choriocarcinoma Protein 1 antibodyAnti-Odd Homeobox Protein 1 antibodyAnti-HOPX antibodyAnti-HOD antibodyAnti-HOP antibodyAnti-LAGY antibodyAnti-NECC1 antibodyAnti-OB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
