• Western blot analysis of extracts of Raji cells, using HLA-DMB antibody (STJ110682) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-HLA-DMB antibody (19-218) (STJ110682)

SKU:
STJ110682

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-HLA-DMB (19-218) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HLA-DMB
Gene ID: 3109
Uniprot ID: DMB_HUMAN
Immunogen Region: 19-218
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-218 of human HLA-DMB (NP_002109.2).
Immunogen Sequence: GGFVAHVESTCLLDDAGTPK DFTYCISFNKDLLTCWDPEE NKMAPCEFGVLNSLANVLSQ HLNQKDTLMQRLRNGLQNCA THTQPFWGSLTNRTRPPSVQ VAKTTPFNTREPVMLACYVW GFYPAEVTITWRKNGKLVMP HSSAHKTAQPNGDWTYQTLS HLALTPSYGDTYTCVVEHTG APEPILRDWTPGLSPMQTLK
Function Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Protein Name Hla Class Ii Histocompatibility Antigen - Dm Beta Chain
Mhc Class Ii Antigen Dmb
Really Interesting New Gene 7 Protein
Database Links Reactome: R-HSA-2132295
Cellular Localisation Late Endosome Membrane
Single-Pass Type I Membrane Protein
Lysosome Membrane
Localizes To Late Endocytic Compartment
Associates With Lysosome Membranes
Alternative Antibody Names Anti-Hla Class Ii Histocompatibility Antigen - Dm Beta Chain antibody
Anti-Mhc Class Ii Antigen Dmb antibody
Anti-Really Interesting New Gene 7 Protein antibody
Anti-HLA-DMB antibody
Anti-DMB antibody
Anti-RING7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance