• Western blot detection of Hexokinase II in COS7, K562 and Hela cell lysates using Hexokinase II mouse mAb (1:1000 diluted).Predicted band size:102KDa.Observed band size:102KDa.

Anti-HK2 antibody [3B9-F8-F10] (STJ99121)

SKU:
STJ99121

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Hexokinase-2 is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: 3B9-F8-F10
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HK2
Gene ID: 3099
Uniprot ID: HXK2_HUMAN
Specificity: This antibody detects endogenous levels of Hexokinase II and does not cross-react with related proteins.
Immunogen: Purified recombinant human Hexokinase II protein fragments expressed in E.coli.
Function Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
Protein Name Hexokinase-2
Hexokinase Type Ii
Hk Ii
Hexokinase-B
Muscle Form Hexokinase
Database Links Reactome: R-HSA-70171
Cellular Localisation Mitochondrion Outer Membrane
Peripheral Membrane Protein
Cytoplasm
Cytosol
The Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrial Outer Membrane
The Interaction With The Mitochondrial Outer Membrane Via The Mitochondrial-Binding Peptide (Mbp) Region Promotes Higher Stability Of The Protein
Release From The Mitochondrial Outer Membrane Into The Cytosol Induces Permeability Transition Pore (Ptp) Opening And Apoptosis
Alternative Antibody Names Anti-Hexokinase-2 antibody
Anti-Hexokinase Type Ii antibody
Anti-Hk Ii antibody
Anti-Hexokinase-B antibody
Anti-Muscle Form Hexokinase antibody
Anti-HK2 antibody

Information sourced from Uniprot.org

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