| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HES6 |
| Gene ID: | 55502 |
| Uniprot ID: | HES6_HUMAN |
| Immunogen Region: | 1-224 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human HES6 (NP_061115.2). |
| Immunogen Sequence: | MAPPAAPGRDRVGREDEDGW ETRGDRKARKPLVEKKRRAR INESLQELRLLLAGAEVQAK LENAEVLELTVRRVQGVLRG RAREREQLQAEASERFAAGY IQCMHEVHTFVSTCQAIDAT VAAELLNHLLESMPLREGSS FQDLLGDALAGPPRAPGRSG WPAGGAPGSPIPSPPGPGDD LCSDLEEAPEAELSQAPAEG PDLVPAALGSLTTAQIARSV WRPW |
| Function | Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation. |
| Protein Name | Transcription Cofactor Hes-6C-Hairy1Class B Basic Helix-Loop-Helix Protein 41Bhlhb41Hairy And Enhancer Of Split 6 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Cofactor Hes-6 antibodyAnti-C-Hairy1 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 41 antibodyAnti-Bhlhb41 antibodyAnti-Hairy And Enhancer Of Split 6 antibodyAnti-HES6 antibodyAnti-BHLHB41 antibody |
Information sourced from Uniprot.org