| Tissue Specificity | Predominantly expressed in hemopoietic cells such as NK cells, subset of T-cells and monocytes. Detected in leukocytes, spleen, and thymus. |
| Post Translational Modifications | Phosphorylated.PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST. O-glycosylated. |
| Function | Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells.this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs).these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells.indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells. |
| Protein Name | Hematopoietic Cell Signal TransducerDnax-Activation Protein 10Membrane Protein Dap10Transmembrane Adapter Protein Kap10 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hematopoietic Cell Signal Transducer antibodyAnti-Dnax-Activation Protein 10 antibodyAnti-Membrane Protein Dap10 antibodyAnti-Transmembrane Adapter Protein Kap10 antibodyAnti-HCST antibodyAnti-DAP10 antibodyAnti-KAP10 antibodyAnti-PIK3AP antibodyAnti-UNQ587 antibodyAnti-PRO1157 antibody |
Information sourced from Uniprot.org
