| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HAND1 (16-215) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HAND1 |
| Gene ID: |
9421 |
| Uniprot ID: |
HAND1_HUMAN |
| Immunogen Region: |
16-215 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 16-215 of human HAND1 (NP_004812.1). |
| Immunogen Sequence: |
PHPAHPMLHEPFLFGPASRC HQERPYFQSWLLSPADAAPD FPAGGPPPAAAAAATAYGPD ARPGQSPGRLEALGGRLGRR KGSGPKKERRRTESINSAFA ELRECIPNVPADTKLSKIKT LRLATSYIAYLMDVLAKDAQ SGDPEAFKAELKKADGGRES KRKRELQQHEGFPPALGPVE KRIKGRTGWPQQVWALELNQ |
| Tissue Specificity | Heart. |
| Post Translational Modifications | Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity. |
| Function | Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes. |
| Protein Name | Heart- And Neural Crest Derivatives-Expressed Protein 1Class A Basic Helix-Loop-Helix Protein 27Bhlha27Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1Ehand |
| Database Links | Reactome: R-HSA-9733709 |
| Cellular Localisation | NucleusNucleoplasmNucleolusInteraction With Mdfic Sequesters It Into The NucleolusPreventing The Transcription Factor ActivityPhosphorylation By Plk4 Disrupts The Interaction With Mdfic And Releases It From The NucleolusLeading To Transcription Factor Activity |
| Alternative Antibody Names | Anti-Heart- And Neural Crest Derivatives-Expressed Protein 1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 27 antibodyAnti-Bhlha27 antibodyAnti-Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1 antibodyAnti-Ehand antibodyAnti-HAND1 antibodyAnti-BHLHA27 antibodyAnti-EHAND antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
