| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GZMH (20-246) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GZMH |
| Gene ID: |
2999 |
| Uniprot ID: |
GRAH_HUMAN |
| Immunogen Region: |
20-246 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-246 of human GZMH (NP_219491.1). |
| Immunogen Sequence: |
EIIGGHEAKPHSRPYMAFVQ FLQEKSRKRCGGILVRKDFV LTAAHCQGSSINVTLGAHNI KEQERTQQFIPVKRPIPHPA YNPKNFSNDIMLLQLERKAK WTTAVRPLRLPSSKAQVKPG QLCSVAGWGYVSMSTLATTL QEVLLTVQKDCQCERLFHGN YSRATEICVGDPKKTQTGFK GDSGGPLVCKDVAQGILSYG NKKGTPPGVYIKVSHFLPWI KRTMKRL |
| Tissue Specificity | Constitutively expressed in NK cells. |
| Function | Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. |
| Protein Name | Granzyme HCcp-XCathepsin G-Like 2Ctsgl2Cytotoxic T-Lymphocyte ProteinaseCytotoxic Serine Protease CCsp-C |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-381426 |
| Cellular Localisation | Cytolytic Granule |
| Alternative Antibody Names | Anti-Granzyme H antibodyAnti-Ccp-X antibodyAnti-Cathepsin G-Like 2 antibodyAnti-Ctsgl2 antibodyAnti-Cytotoxic T-Lymphocyte Proteinase antibodyAnti-Cytotoxic Serine Protease C antibodyAnti-Csp-C antibodyAnti-GZMH antibodyAnti-CGL2 antibodyAnti-CTSGL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
