| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRM5 |
| Gene ID: | 2915 |
| Uniprot ID: | GRM5_HUMAN |
| Immunogen Region: | 870-1212 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 870-1070 of human GRM5 (NP_001137303.1). |
| Immunogen Sequence: | GSSGETLRYKDRRLAQHKSE IECFTPKGSMGNGGRATMSS SNGKSVTWAQNEKSSRGQHL WQRLSIHINKKENPNQTAVI KPFPKSTESRGLGAGAGAGG SAGGVGATGGAGCAGAGPGG PESPDAGPKALYDVAEAEEH FPAPARPRSPSPISTLSHRA GSASRTDDDVPSLHSEPVAR SSSSQGSLMEQISSVVTRFT A |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
| Protein Name | Metabotropic Glutamate Receptor 5Mglur5 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499Reactome: R-HSA-6794361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 5 antibodyAnti-Mglur5 antibodyAnti-GRM5 antibodyAnti-GPRC1E antibodyAnti-MGLUR5 antibody |
Information sourced from Uniprot.org