| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPR171 |
| Gene ID: |
29909 |
| Uniprot ID: |
GP171_HUMAN |
| Immunogen Region: |
100-200 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GPR171 (NP_037440.3). |
| Immunogen Sequence: |
LSIIFLAFVSIDRCLQLTHS CKIYRIQEPGFAKMISTVVW LMVLLIMVPNMMIPIKDIKE KSNVGCMEFKKEFGRNWHLL TNFICVAIFLNFSAIILISN C |
| Tissue Specificity | Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes. Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level). |
| Function | G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception. Acts as a negative regulator T cell function. |
| Protein Name | G-Protein Coupled Receptor 171G-Protein Coupled Receptor H963 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinColocalized With Gpr83 In The Paraventricular Nucleus |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 171 antibodyAnti-G-Protein Coupled Receptor H963 antibodyAnti-GPR171 antibodyAnti-H963 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
