| Tissue Specificity | Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes. Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level). |
| Function | G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception. Acts as a negative regulator T cell function. |
| Protein Name | G-Protein Coupled Receptor 171G-Protein Coupled Receptor H963 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinColocalized With Gpr83 In The Paraventricular Nucleus |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 171 antibodyAnti-G-Protein Coupled Receptor H963 antibodyAnti-GPR171 antibodyAnti-H963 antibody |
Information sourced from Uniprot.org
