| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPD1L (1-351) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPD1L |
| Gene ID: |
23171 |
| Uniprot ID: |
GPD1L_HUMAN |
| Immunogen Region: |
1-351 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human GPD1L (NP_055956.1). |
| Immunogen Sequence: |
MAAAPLKVCIVGSGNWGSAV AKIIGNNVKKLQKFASTVKM WVFEETVNGRKLTDIINNDH ENVKYLPGHKLPENVVAMSN LSEAVQDADLLVFVIPHQFI HRICDEITGRVPKKALGITL IKGIDEGPEGLKLISDIIRE KMGIDISVLMGANIANEVAA EKFCETTIGSKVMENGLLFK ELLQTPNFRITVVDDADTVE LCGALKNIVAVGAGFCDGLR CGDNTKAAVIRLGLMEMIA |
| Tissue Specificity | Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs. |
| Function | Plays a role in regulating cardiac sodium current.decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current.cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. |
| Protein Name | Glycerol-3-Phosphate Dehydrogenase 1-Like ProteinGpd1-L |
| Database Links | Reactome: R-HSA-1483166 |
| Cellular Localisation | CytoplasmLocalized To The Region Of The Plasma Membrane |
| Alternative Antibody Names | Anti-Glycerol-3-Phosphate Dehydrogenase 1-Like Protein antibodyAnti-Gpd1-L antibodyAnti-GPD1L antibodyAnti-KIAA0089 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
