Host: |
Rabbit |
Applications: |
WB/IHC-P/IF/ICC/ELISA |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
GOT1 |
Gene ID: |
2805 |
Uniprot ID: |
AATC_HUMAN |
Immunogen Region: |
244-413 |
Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 244-413 of human GOT1 (NP_002070.1). |
Immunogen Sequence: |
FVSEGFEFFCAQSFSKNFGL YNERVGNLTVVGKEPESILQ VLSQMEKIVRITWSNPPAQG ARIVASTLSNPELFEEWTGN VKTMADRILTMRSELRARLE ALKTPGTWNHITDQIGMFSF TGLNPKQVEYLVNEKHIYLL PSGRINVSGLTTKNLDYVAT SIHEAVTKIQ |
Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway. |
Protein Name | Aspartate Aminotransferase - CytoplasmicCaspatCysteine Aminotransferase - CytoplasmicCysteine Transaminase - CytoplasmicCcatGlutamate Oxaloacetate Transaminase 1Transaminase A |
Database Links | Reactome: R-HSA-1237112Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Aspartate Aminotransferase - Cytoplasmic antibodyAnti-Caspat antibodyAnti-Cysteine Aminotransferase - Cytoplasmic antibodyAnti-Cysteine Transaminase - Cytoplasmic antibodyAnti-Ccat antibodyAnti-Glutamate Oxaloacetate Transaminase 1 antibodyAnti-Transaminase A antibodyAnti-GOT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance