• Western blot analysis of extracts of various cell lines, using GFRA1 antibody (STJ116191) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-GFRA1 antibody (25-280) (STJ116191)

SKU:
STJ116191

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GFRA1 (25-280) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GFRA1
Gene ID: 2674
Uniprot ID: GFRA1_HUMAN
Immunogen Region: 25-280
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human GFRA1 (NP_665736.1).
Immunogen Sequence: DRLDCVKASDQCLKEQSCST KYRTLRQCVAGKETNFSLAS GLEAKDECRSAMEALKQKSL YNCRCKRGMKKEKNCLRIYW SMYQSLQGNDLLEDSPYEPV NSRLSDIFRVVPFISVEHIP KGNNCLDAAKACNLDDICKK YRSAYITPCTTSVSNDVCNR RKCHKALRQFFDKVPAKHSY GMLFCSCRDIACTERRRQTI VPVCSYEEREKPNCLNLQDS CKTNYICRSRLADFFTNCQ
Function Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
Protein Name Gdnf Family Receptor Alpha-1
Gdnf Receptor Alpha-1
Gdnfr-Alpha-1
Gfr-Alpha-1
Ret Ligand 1
Tgf-Beta-Related Neurotrophic Factor Receptor 1
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Trans-Golgi Network
Endosome
Multivesicular Body
Localizes Mainly To The Plasma Membrane
In The Presence Of Sorl1
Shifts To Vesicular Structures
Including Trans-Golgi Network
Endosomes And Multivesicular Bodies
Alternative Antibody Names Anti-Gdnf Family Receptor Alpha-1 antibody
Anti-Gdnf Receptor Alpha-1 antibody
Anti-Gdnfr-Alpha-1 antibody
Anti-Gfr-Alpha-1 antibody
Anti-Ret Ligand 1 antibody
Anti-Tgf-Beta-Related Neurotrophic Factor Receptor 1 antibody
Anti-GFRA1 antibody
Anti-GDNFRA antibody
Anti-RETL1 antibody
Anti-TRNR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance