| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GABRG2 (400-500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GABRG2 |
| Gene ID: |
2566 |
| Uniprot ID: |
GBRG2_HUMAN |
| Immunogen Region: |
400-500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 400-500 of human GABRG2 (NP_944493.2). |
| Immunogen Sequence: |
VSNRKPSKDKDKKKKNPLLR MFSFKAPTIDIRPRSATIQM NNATHLQERDEEYGYECLDG KDCASFFCCFEDCRTGAWRH GRIHIRIAKMDSYARIFFPT A |
| Post Translational Modifications | Glycosylated. Palmitoylated by ZDHHC3/GODZ.required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses. |
| Function | Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Gamma-2Gaba(A Receptor Subunit Gamma-2 |
| Database Links | Reactome: R-HSA-1236394Reactome: R-HSA-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCell ProjectionDendriteCytoplasmic Vesicle Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Gamma-2 antibodyAnti-Gaba(A Receptor Subunit Gamma-2 antibodyAnti-GABRG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
