| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FMO2 (210-470) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FMO2 |
| Gene ID: |
2327 |
| Uniprot ID: |
FMO2_HUMAN |
| Immunogen Region: |
210-470 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-470 of human FMO2 (NP_001451.2). |
| Immunogen Sequence: |
VFISTRHGTWVMSRISEDGY PWDSVFHTRFRSMLRNVLPR TAVKWMIEQQMNRWFNHENY GLEPQNKYIMKEPVLNDDVP SRLLCGAIKVKSTVKELTET SAIFEDGTVEENIDVIIFAT GYSFSFPFLEDSLVKVENNM VSLYKYIFPAHLDKSTLACI GLIQPLGSIFPTAELQARWV TRVFKGLCSLPSERTMMMDI IKRNEKRIDLFGESQSQTLQ TNYVDYLDELALEIGAKPD |
| Tissue Specificity | Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. |
| Function | Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton. |
| Protein Name | Flavin-Containing Monooxygenase 2Dimethylaniline Oxidase 2Fmo 1b1Pulmonary Flavin-Containing Monooxygenase 2Fmo 2 |
| Database Links | Reactome: R-HSA-217271 |
| Cellular Localisation | Microsome MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 2 antibodyAnti-Dimethylaniline Oxidase 2 antibodyAnti-Fmo 1b1 antibodyAnti-Pulmonary Flavin-Containing Monooxygenase 2 antibodyAnti-Fmo 2 antibodyAnti-FMO2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
