| Function | Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. |
| Protein Name | Polyphosphoinositide Phosphatase Phosphatidylinositol 3 -5-Bisphosphate 5-PhosphataseSac Domain-Containing Protein 3Serine-Protein Phosphatase Fig4 |
| Database Links | Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | Endosome MembraneLocalization Requires Vac14 And Pikfyve |
| Alternative Antibody Names | Anti-Polyphosphoinositide Phosphatase antibodyAnti-Phosphatidylinositol 3 -5-Bisphosphate 5-Phosphatase antibodyAnti-Sac Domain-Containing Protein 3 antibodyAnti-Serine-Protein Phosphatase Fig4 antibodyAnti-FIG4 antibodyAnti-KIAA0274 antibodyAnti-SAC3 antibody |
Information sourced from Uniprot.org
