| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FHL2 (1-279) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FHL2 |
| Gene ID: |
2274 |
| Uniprot ID: |
FHL2_HUMAN |
| Immunogen Region: |
1-279 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-279 of human FHL2 (NP_001034581.1). |
| Immunogen Sequence: |
MTERFDCHHCNESLFGKKYI LREESPYCVVCFETLFANTC EECGKPIGCDCKDLSYKDRH WHEACFHCSQCRNSLVDKPF AAKEDQLLCTDCYSNEYSSK CQECKKTIMPGTRKMEYKGS SWHETCFICHRCQQPIGTKS FIPKDNQNFCVPCYEKQHAM QCVQCKKPITTGGVTYREQP WHKECFVCTACRKQLSGQRF TARDDFAYCLNCFCDLYAKK CAGCTNPISGLGGTKYISF |
| Tissue Specificity | Expressed in skeletal muscle and heart. |
| Function | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. |
| Protein Name | Four And A Half Lim Domains Protein 2Fhl-2Lim Domain Protein DralSkeletal Muscle Lim-Protein 3Slim-3 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | CytoplasmNucleusMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Four And A Half Lim Domains Protein 2 antibodyAnti-Fhl-2 antibodyAnti-Lim Domain Protein Dral antibodyAnti-Skeletal Muscle Lim-Protein 3 antibodyAnti-Slim-3 antibodyAnti-FHL2 antibodyAnti-DRAL antibodyAnti-SLIM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
