| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FGD5 (1000-1200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FGD5 |
| Gene ID: |
152273 |
| Uniprot ID: |
FGD5_HUMAN |
| Immunogen Region: |
1000-1200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human FGD5 (NP_689749.3). |
| Immunogen Sequence: |
YLGLLSENCLHSPRLAAAVR EFEQSVQGGSQTAKHRLLRV VQRLFQYQVLLTDYLNNLCP DSAEYDNTQGALSLISKVTD RANDSMEQGENLQKLVHIEH SVRGQGDLLQPGREFLKEGT LMKVTGKNRRPRHLFLMNDV LLYTYPQKDGKYRLKNTLAV ANMKVSRPVMEKVPYALKIE TSESCLMLSASSCAERDEWY G |
| Tissue Specificity | Expressed in endothelial cells (at protein level). |
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. |
| Protein Name | Fyve - Rhogef And Ph Domain-Containing Protein 5Zinc Finger Fyve Domain-Containing Protein 23 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembraneEndoplasmic ReticulumGolgi ApparatusEarly EndosomeIn Peripheral Membrane RufflesColocolizes With F-ActinIn Confluent HuvecsDetected At Cell-Cell-Contact Sites Where It Colocalizes With Vascular Endothelial Cadherin/Cdh5 |
| Alternative Antibody Names | Anti-Fyve - Rhogef And Ph Domain-Containing Protein 5 antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 23 antibodyAnti-FGD5 antibodyAnti-ZFYVE23 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
