| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FGD5 |
| Gene ID: | 152273 |
| Uniprot ID: | FGD5_HUMAN |
| Immunogen Region: | 1000-1200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human FGD5 (NP_689749.3). |
| Immunogen Sequence: | YLGLLSENCLHSPRLAAAVR EFEQSVQGGSQTAKHRLLRV VQRLFQYQVLLTDYLNNLCP DSAEYDNTQGALSLISKVTD RANDSMEQGENLQKLVHIEH SVRGQGDLLQPGREFLKEGT LMKVTGKNRRPRHLFLMNDV LLYTYPQKDGKYRLKNTLAV ANMKVSRPVMEKVPYALKIE TSESCLMLSASSCAERDEWY G |
| Tissue Specificity | Expressed in endothelial cells (at protein level). |
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. |
| Protein Name | Fyve - Rhogef And Ph Domain-Containing Protein 5 Zinc Finger Fyve Domain-Containing Protein 23 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection Ruffle Membrane Endoplasmic Reticulum Golgi Apparatus Early Endosome In Peripheral Membrane Ruffles Colocolizes With F-Actin In Confluent Huvecs Detected At Cell-Cell-Contact Sites Where It Colocalizes With Vascular Endothelial Cadherin/Cdh5 |
| Alternative Antibody Names | Anti-Fyve - Rhogef And Ph Domain-Containing Protein 5 antibody Anti-Zinc Finger Fyve Domain-Containing Protein 23 antibody Anti-FGD5 antibody Anti-ZFYVE23 antibody |
Information sourced from Uniprot.org