| Function | Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit GammaFc Receptor Gamma-ChainFcrgammaFc-Epsilon Ri-GammaIge Fc Receptor Subunit GammaFceri Gamma |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202733Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837Reactome: R-HSA-5621480Reactome: R-HSA-6798695Reactome: R-HSA-75892 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma antibodyAnti-Fc Receptor Gamma-Chain antibodyAnti-Fcrgamma antibodyAnti-Fc-Epsilon Ri-Gamma antibodyAnti-Ige Fc Receptor Subunit Gamma antibodyAnti-Fceri Gamma antibodyAnti-FCER1G antibody |
Information sourced from Uniprot.org
