| Tissue Specificity | Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. |
| Function | Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. |
| Protein Name | Protein Lifeguard 2Fas Apoptotic Inhibitory Molecule 2Neural Membrane Protein 35Transmembrane Bax Inhibitor Motif-Containing Protein 2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembrane RaftPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Protein Lifeguard 2 antibodyAnti-Fas Apoptotic Inhibitory Molecule 2 antibodyAnti-Neural Membrane Protein 35 antibodyAnti-Transmembrane Bax Inhibitor Motif-Containing Protein 2 antibodyAnti-FAIM2 antibodyAnti-KIAA0950 antibodyAnti-LFG antibodyAnti-LFG2 antibodyAnti-NMP35 antibodyAnti-TMBIM2 antibody |
Information sourced from Uniprot.org
