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Primary Antibodies
Polyclonal Antibodies
Anti-FADD antibody (1-208) (STJ11100017)

Western blot analysis of lysates from wild type (WT) and FADD knockout (KO) HeLa cells, using [KO Validated] FADD Rabbit polyclonal antibody (STJ11100017) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-FADD antibody (1-208) (STJ11100017)

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STJ11100017

£212.50 - £501.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FADD (1-208) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FADD
Gene ID:	8772
Uniprot ID:	FADD_HUMAN
Immunogen Region:	1-208
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1).
Immunogen Sequence:	MDPFLVLLHSVSSSLSSSEL TELKFLCLGRVGKRKLERVQ SGLDLFSMLLEQNDLEPGHT ELLRELLASLRRHDLLRRVD DFEAGAAAGAAPGEEDLCAA FNVICDNVGKDWRRLARQLK VSDTKIDSIEDRYPRNLTER VRESLRIWKNTEKENATVAH LVGALRSCQMNLVADLVQEV QQARDLQNRSGAMSPMSWNS DASTSEAS

Tissue Specificity	Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Post Translational Modifications	(Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors.
Function	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Protein Name	Fas-Associated Death Domain Protein Fas-Associating Death Domain-Containing Protein Growth-Inhibiting Gene 3 Protein Mediator Of Receptor Induced Toxicity
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-2562578 Reactome: R-HSA-3371378 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5675482 Reactome: R-HSA-69416 Reactome: R-HSA-75157 Reactome: R-HSA-75158 Reactome: R-HSA-9013957 Reactome: R-HSA-933543 Reactome: R-HSA-9693928
Alternative Antibody Names	Anti-Fas-Associated Death Domain Protein antibody Anti-Fas-Associating Death Domain-Containing Protein antibody Anti-Growth-Inhibiting Gene 3 Protein antibody Anti-Mediator Of Receptor Induced Toxicity antibody Anti-FADD antibody Anti-MORT1 antibody Anti-GIG3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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