| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FABP6 (1-128) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FABP6 |
| Gene ID: |
2172 |
| Uniprot ID: |
FABP6_HUMAN |
| Immunogen Region: |
1-128 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human FABP6 (NP_001436.1). |
| Immunogen Sequence: |
MAFTGKFEMESEKNYDEFMK LLGISSDVIEKARNFKIVTE VQQDGQDFTWSQHYSGGHTM TNKFTVGKESNIQTMGGKTF KATVQMEGGKLVVNFPNYHQ TSEIVGDKLVEVSTIGGVTY ERVSKRLA |
| Tissue Specificity | Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). |
| Function | Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion. Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. |
| Protein Name | GastrotropinGtFatty Acid-Binding Protein 6Ileal Lipid-Binding ProteinIlbpIntestinal 15 Kda ProteinI-15pIntestinal Bile Acid-Binding ProteinI-Babp |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-163560Reactome: R-HSA-9623433 |
| Cellular Localisation | Isoform 1: CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideIsoform 2: CytoplasmLocalized Close To Nucleus On The Apical Side Of Both Normal And Neoplastic Cells |
| Alternative Antibody Names | Anti-Gastrotropin antibodyAnti-Gt antibodyAnti-Fatty Acid-Binding Protein 6 antibodyAnti-Ileal Lipid-Binding Protein antibodyAnti-Ilbp antibodyAnti-Intestinal 15 Kda Protein antibodyAnti-I-15p antibodyAnti-Intestinal Bile Acid-Binding Protein antibodyAnti-I-Babp antibodyAnti-FABP6 antibodyAnti-ILBP antibodyAnti-ILLBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
