| Tissue Specificity | Produced abundantly in a wide variety of cell types. |
| Function | RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility. |
| Protein Name | 40-Kda Huntingtin-Associated ProteinHap40Cpg Island ProteinFactor Viii Intron 22 Protein |
| Cellular Localisation | CytoplasmNucleusEarly EndosomeNuclear BodyDiffuse Presence In The Cytoplasm And Accumulation In The NucleusIn Absence Of HttF8a1/F8a2/F8a3 Is Concentred In CytoplasmColocalized With Htt In EndosomesIn Neuron Found In Intranuclear StructuresThe Intranuclear Rodlets (Inrs)Also Known As Rodlets Of RoncoroniIn Association With Ubiquitin |
| Alternative Antibody Names | Anti-40-Kda Huntingtin-Associated Protein antibodyAnti-Hap40 antibodyAnti-Cpg Island Protein antibodyAnti-Factor Viii Intron 22 Protein antibodyAnti-F8A1.F8A2.F8A3 antibody |
Information sourced from Uniprot.org
