| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EXOSC7 |
| Gene ID: | 23016 |
| Uniprot ID: | EXOS7_HUMAN |
| Immunogen Region: | 1-291 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-291 of human EXOSC7 (NP_055819.2). |
| Immunogen Sequence: | MASVTLSEAEKVYIVHGVQE DLRVDGRGCEDYRCVEVETD VVSNTSGSARVKLGHTDILV GVKAEMGTPKLEKPNEGYLE FFVDCSASATPEFEGRGGDD LGTEIANTLYRIFNNKSSVD LKTLCISPREHCWVLYVDVL LLECGGNLFDAISIAVKAAL FNTRIPRVRVLEDEEGSKDI ELSDDPYDCIRLSVENVPCI VTLCKIGYRHVVDATLQEEA CSLASLLVSVTSKGVVTCM |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
| Protein Name | Exosome Complex Component Rrp42 Exosome Component 7 Ribosomal Rna-Processing Protein 42 P8 |
| Database Links | Reactome: R-HSA-380994 Reactome: R-HSA-429958 Reactome: R-HSA-450385 Reactome: R-HSA-450513 Reactome: R-HSA-450604 Reactome: R-HSA-6791226 |
| Cellular Localisation | Nucleus Nucleolus Cytoplasm |
| Alternative Antibody Names | Anti-Exosome Complex Component Rrp42 antibody Anti-Exosome Component 7 antibody Anti-Ribosomal Rna-Processing Protein 42 antibody Anti-P8 antibody Anti-EXOSC7 antibody Anti-KIAA0116 antibody Anti-RRP42 antibody |
Information sourced from Uniprot.org