| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERCC6L |
| Gene ID: | 54821 |
| Uniprot ID: | ERC6L_HUMAN |
| Immunogen Region: | 300-400 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ERCC6L (NP_060139.2). |
| Immunogen Sequence: | KDATPGEKALGFKISENLMA IIKPYFLRRTKEDVQKKKSS NPEARLNEKNPDVDAICEMP SLSRKNDLIIWIRLVPLQEE IYRKFVSLDHIKELLMETRS P |
| Post Translational Modifications | Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region. |
| Function | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). |
| Protein Name | Dna Excision Repair Protein Ercc-6-Like Atp-Dependent Helicase Ercc6-Like Plk1-Interacting Checkpoint Helicase Tumor Antigen Bj-Hcc-15 |
| Database Links | Reactome: R-HSA-141444 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-5663220 Reactome: R-HSA-68877 Reactome: R-HSA-9648025 |
| Cellular Localisation | Chromosome Centromere Kinetochore Localizes To Kinetochores Inner Centromeres And Thin Threads Connecting Separating Chromosomes Even During Anaphase In Prometaphase Cells It Mostly Concentrates In Between Kinetochores In Metaphase It Localizes To Numerous Thin Threads That Stretch Between Sister Kinetochores Of The Aligned Chromosomes And Are Composed Of Catenated Centromeric Dna Evolution From Inner Centromeres To Thin Threads Takes Place In Response To Tension Resolution Of Thin Threads Requires Topoisomerase 2-Alpha (Top2a) After Anaphase Onset |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-6-Like antibody Anti-Atp-Dependent Helicase Ercc6-Like antibody Anti-Plk1-Interacting Checkpoint Helicase antibody Anti-Tumor Antigen Bj-Hcc-15 antibody Anti-ERCC6L antibody Anti-PICH antibody |
Information sourced from Uniprot.org