| Tissue Specificity | Widely expressed. Abundant in brain, placenta, liver and pancreas, followed by heart, skeletal muscle, lung and kidney. In brain it is strongly expressed in cerebellum, followed by the occipital pole and the frontal lobe. |
| Function | Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine (PE) from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and also catalyzes the synthesis of plasmanyl-PE, a lipid required for proper myelination and neurodevelopment, from 1-alkyl-2-acylglycerol. |
| Protein Name | Ethanolaminephosphotransferase 1Hept1Selenoprotein ISeli |
| Database Links | Reactome: R-HSA-1483213 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ethanolaminephosphotransferase 1 antibodyAnti-Hept1 antibodyAnti-Selenoprotein I antibodyAnti-Seli antibodyAnti-SELENOI antibodyAnti-EPT1 antibodyAnti-KIAA1724 antibodyAnti-SELI antibody |
Information sourced from Uniprot.org
