| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ENTPD4 |
| Gene ID: | 9583 |
| Uniprot ID: | ENTP4_HUMAN |
| Immunogen Region: | 350-470 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-470 of human ENTPD4 (NP_001122402.1). |
| Immunogen Sequence: | LTPDMPYLDPCLPLDIKDEI QQNGQTIYLRGTGDFDLCRE TIQPFMNKTNETQTSLNGVY QPPIHFQNSEFYGFSEFYYC TEDVLRMGGDYNAAKFTKAA KDYCATKWSILRERFDRGLY A |
| Tissue Specificity | Ubiquitous. Highest expression in testis and lowest in bladder. |
| Function | Isoform 1: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates. Preferentially activated by Ca(2+) over Mg(2+). Isoform 2: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. |
| Protein Name | Ectonucleoside Triphosphate Diphosphohydrolase 4 Ntpdase 4 Golgi Udpase Lysosomal Apyrase-Like Protein Of 70 Kda Uridine-Diphosphatase Udpase |
| Database Links | Reactome: R-HSA-8850843 |
| Cellular Localisation | Isoform 1: Cytoplasmic Vesicle Autophagosome Membrane Multi-Pass Membrane Protein Lysosome Membrane Isoform 2: Golgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Ectonucleoside Triphosphate Diphosphohydrolase 4 antibody Anti-Ntpdase 4 antibody Anti-Golgi Udpase antibody Anti-Lysosomal Apyrase-Like Protein Of 70 Kda antibody Anti-Uridine-Diphosphatase antibody Anti-Udpase antibody Anti-ENTPD4 antibody Anti-KIAA0392 antibody Anti-LALP70 antibody Anti-LYSAL1 antibody |
Information sourced from Uniprot.org