| Function | S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Ribosomal Rna Small Subunit Methyltransferase Nep118s RrnaPseudouridine(1248-N1-Methyltransferase18s Rrna Psi1248 MethyltransferaseNucleolar Protein Emg1 HomologProtein C2fRibosome Biogenesis Protein Nep1 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Ribosomal Rna Small Subunit Methyltransferase Nep1 antibodyAnti-18s Rrna antibodyAnti-Pseudouridine(1248-N1-Methyltransferase antibodyAnti-18s Rrna Psi1248 Methyltransferase antibodyAnti-Nucleolar Protein Emg1 Homolog antibodyAnti-Protein C2f antibodyAnti-Ribosome Biogenesis Protein Nep1 antibodyAnti-EMG1 antibodyAnti-C2F antibody |
Information sourced from Uniprot.org
