| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ELK4 |
| Gene ID: | 2005 |
| Uniprot ID: | ELK4_HUMAN |
| Immunogen Region: | 150-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-300 of human ELK4 (NP_068567.1). |
| Immunogen Sequence: | FTLNSLNSSNVKLFKLIKTE NPAEKLAEKKSPQEPTPSVI KFVTTPSKKPPVEPVAATIS IGPSISPSSEETIQALETLV SPKLPSLEAPTSASNVMTAF ATTPPISSIPPLQEPPRTPS PPLSSHPDIDTDIDSVASQP MELPENLSLEP |
| Function | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. |
| Protein Name | Ets Domain-Containing Protein Elk-4Serum Response Factor Accessory Protein 1Sap-1Srf Accessory Protein 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets Domain-Containing Protein Elk-4 antibodyAnti-Serum Response Factor Accessory Protein 1 antibodyAnti-Sap-1 antibodyAnti-Srf Accessory Protein 1 antibodyAnti-ELK4 antibodyAnti-SAP1 antibody |
Information sourced from Uniprot.org