| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ELK4 (150-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ELK4 |
| Gene ID: |
2005 |
| Uniprot ID: |
ELK4_HUMAN |
| Immunogen Region: |
150-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 150-300 of human ELK4 (NP_068567.1). |
| Immunogen Sequence: |
FTLNSLNSSNVKLFKLIKTE NPAEKLAEKKSPQEPTPSVI KFVTTPSKKPPVEPVAATIS IGPSISPSSEETIQALETLV SPKLPSLEAPTSASNVMTAF ATTPPISSIPPLQEPPRTPS PPLSSHPDIDTDIDSVASQP MELPENLSLEP |
| Function | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. |
| Protein Name | Ets Domain-Containing Protein Elk-4Serum Response Factor Accessory Protein 1Sap-1Srf Accessory Protein 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets Domain-Containing Protein Elk-4 antibodyAnti-Serum Response Factor Accessory Protein 1 antibodyAnti-Sap-1 antibodyAnti-Srf Accessory Protein 1 antibodyAnti-ELK4 antibodyAnti-SAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
