| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF3I |
| Gene ID: | 8668 |
| Uniprot ID: | EIF3I_HUMAN |
| Immunogen Region: | 1-325 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human EIF3I (NP_003748.1). |
| Immunogen Sequence: | MKPILLQGHERSITQIKYNR EGDLLFTVAKDPIVNVWYSV NGERLGTYMGHTGAVWCVDA DWDTKHVLTGSADNSCRLWD CETGKQLALLKTNSAVRTCG FDFGGNIIMFSTDKQMGYQC FVSFFDLRDPSQIDNNEPYM KIPCNDSKITSAVWGPLGEC IIAGHESGELNQYSAKSGEV LVNVKEHSRQINDIQLSRDM TMFVTASKDNTAKLFDSTTL EHQKTFRTERPVNSAALSP |
| Post Translational Modifications | Phosphorylated by TGF-beta type II receptor. |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit I Eif3i Eukaryotic Translation Initiation Factor 3 Subunit 2 Tgf-Beta Receptor-Interacting Protein 1 Trip-1 Eif-3-Beta Eif3 P36 |
| Database Links | Reactome: R-HSA-156827 Reactome: R-HSA-72649 Reactome: R-HSA-72689 Reactome: R-HSA-72695 Reactome: R-HSA-72702 Reactome: R-HSA-72706 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 3 Subunit I antibody Anti-Eif3i antibody Anti-Eukaryotic Translation Initiation Factor 3 Subunit 2 antibody Anti-Tgf-Beta Receptor-Interacting Protein 1 antibody Anti-Trip-1 antibody Anti-Eif-3-Beta antibody Anti-Eif3 P36 antibody Anti-EIF3I antibody Anti-EIF3S2 antibody Anti-TRIP1 antibody |
Information sourced from Uniprot.org